GcMAF (DBP) D-Binding Protein

[B & T Cell Enzymes, Glucose into Pyruvic Acid (Ketone), ATP & Nicotinamide]

GcMAF (Gc protein-derived macrophage activating factor) is a protein produced by modification of vitamin D-binding protein.

Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein (the Gc protein), which is naturally promoted by lymphocytes (B and T cells). The resulting protein may be a macrophage activating factor (MAF). MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvic acid, CH3COCOOH. The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine dinucleotide (NADH). Glycolysis is a sequence of ten reactions catalyzed by enzymes.

Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO, is an intermediate in several metabolic pathways throughout the cell.

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Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells

https://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC2956649/