mycoplasma manufactures hydrogen peroxide within cells, this oxidative stress reduces P53, causing Cellular Senescence (Zombie Cells)

Cellular Senescence
Zombie Cells

https://en.m.wikipedia.org/wiki/Cellular_senescence

https://alternative-doctor.com/what-are-zombie-cells-and-how-do-we-get-rid-of-them/

Senescent cells are aged cells that stop functioning properly and can cause damage to surrounding tissues. They lose the ability to grow or divide, and yet they refuse to die off, so they are a bit like “zombie cells.”

It’s worse: these senescent cells spew out compounds that incite harmful systemic inflammation, inflicting even more damage. Senescent cells are a major driver of age-related disease and dysfunction. They even accelerate the aging process itself.

Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture

https://ashpublications.org/blood/article/104/13/4252/18956/Mycoplasma-fermentans-infection-promotes

Classification and Treatment of Diseases in the Age of Genome Medicine Based on Pathway Pathology

https://pubmed.ncbi.nlm.nih.gov/34502326/

two key cellular pathways, i.e., the cellular senescence of normal cells and the immortality of cancer cells, and by contrasting single cell/single pathway diseases, such as mycoplasma and coughing pneumonia, with complex diseases such as cancer, with multiple cell types as well as multiple affected cellular and signaling pathways.

Dr. Leonard Hayflick made basic discoveries in pathway pathology not only by identifying cells causing disease (Mycoplasma pneumoniae) and establishing cell strains for treating disease (WI-38 for viral vaccines), but also by first describing cellular senescence and immortality.

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Mycoplasma infection suppresses p53, activates NF-κB and cooperates with oncogenic Ras in rodent fibroblast transformation

https://www.nature.com/articles/onc2008103

Role of p53 in the Regulation of Cellular Senescence

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7175209/

Stressors include both intrinsic factors, such as oxidative damage, telomere attrition, hyperproliferation, oncogene activation, and environmental sources, including UV-light, γ-irradiation, and chemotherapeutic drugs.

Dietary Polyphenols and Their Biological Significance

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3871896/

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Siloxane

https://en.m.wikipedia.org/wiki/Siloxane