natrual minimal genome mycoplasmas are species specific symbiont parasite by evolution of infection, lacking many DNA functions to live anywhere else then the specific species, mimicking the same chemicals to remain a stealth pathogen, artificial or weaponized gain of function is making it transmitted cross species.
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wonder is coli & yeast found in insects are used for gain of function of symbionts identical to the definition of a virus?
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Engineering yeast endosymbionts as a step toward the evolution of mitochondria
Strategy to engineer S. cerevisiae E. coli endosymbiont chimera.
https://www.pnas.org/content/115/46/11796
Cloning, sequence analysis and expression in Escherichia coli of the gene encoding a uricase from the yeast-like symbiont of the brown planthopper, Nilaparvata lugens
https://pubmed.ncbi.nlm.nih.gov/10696593/
Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids
https://pubmed.ncbi.nlm.nih.gov/31239480/
Expression of bioactive soluble human stem cell factor (SCF) from recombinant Escherichia coli by coproduction of thioredoxin and efficient purification using arginine in affinity chromatography
RE: Disease-X