Possible Interaction: Gamma-Aminobutyric Acid and Ivermectin

https://supp.ai/i/gamma-aminobutyric-acid-ivermectin/C0016904-C0022322

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

https://www.sciencedirect.com/science/article/abs/pii/S1043661820315152

Ivermectin kills a variety of parasites and insects, including the Anopheline vectors of malaria parasites.

https://pubmed.ncbi.nlm.nih.gov/28438169/

Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.

Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The selective activity of compounds of this class is attributable to the facts that some mammals do not have glutamate-gated chloride channels and that the avermectins have a low affinity for mammalian ligand-gated chloride channels. Ivermectin does not readily cross the blood-brain barrier in humans.

..

Ivermectin
Dihydroavermectin
Nicotinic Receptor
Alpha-7 (a7)
Nicotinic AChR (nAChR)
Nicotinic Acid (Niacin)

Nicotinic Acetylcholine Receptor

Allosteric Modulator of α7 nAChR P2X4 Receptor

Ligand Gated Ion Channel

Glutamate Gated Chloride Channels (GABA)

https://en.m.wikipedia.org/wiki/Alpha-7_nicotinic_receptor

https://en.m.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor

https://en.m.wikipedia.org/wiki/Ligand-gated_ion_channel

..

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

https://www.researchgate.net/publication/13766357_Ivermectin_A_Positive_Allosteric_Effector_of_the_a7_Neuronal_Nicotinic_Acetylcholine_Receptor

..

GABA
Gamma-Aminobutyric Acid

GABA
Glutamate Gated Chloride Channels

There are two classes of GABA receptors:

GABA-A and GABA-B

GABA-A receptors are ligand-gated ion channels (ionotropic receptors).

GABA-B receptors are G protein-coupled receptors, (metabotropic receptors).

Opioid Receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.

..

Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes

https://www.researchgate.net/publication/6598825_Functional_characterization_of_Musca_glutamate-_and_GABA-gated_chloride_channels_expressed_independently_and_coexpressed_in_Xenopus_oocytes

..

Inhibitory Glutamate Receptors (IGluRs)

https://en.m.wikipedia.org/wiki/Glutamate_receptor

Glutamate synthase is a complex iron-sulfur flavoprotein that forms L-glutamate from L-glutamine and 2-oxoglutarate. It participates with glutamine synthetase in ammonia assimilation processes.

..

all of the NAC is a Sulfur derivatives.

Niacin Nicotinic Acid Nicotine are all derivatives of Nitrogen.