Poppers
Alkyl Nitrites
Quinine Total Synthesis

https://poppersmyth.typepad.com/aids_and_poppers/

https://en.m.wikipedia.org/wiki/Alkyl_nitrites

https://en.m.wikipedia.org/wiki/Poppers

https://en.m.wikipedia.org/wiki/Quinine_total_synthesis

https://en.m.wikipedia.org/wiki/Mauveine

https://en.m.wikipedia.org/wiki/Aniline

https://drugscience.org.uk/drug-information/alkyl-nitrites/#082939092157033

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Overdose the chemical converts red haemoglobin in the blood into methemoglobin, turning the blood chocolate brown. Haemoglobin is needed to deliver oxygen round the body, so the result of severe ‘methemoglobinemia’ is oxygen starvation, potentially leading to organ failure, blindness, brain damage, or in the worse cases, death.

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Woodward–Doering formal quinine total synthesis

ring opening with the alkyl nitrite ethyl nitrite with sodium ethoxide in ethanol.

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Quinine total synthesis

Only the cis isomer crystallizes and used in the next reaction step, a ring opening with the alkyl nitriteethyl nitrite with sodium ethoxide in ethanol to 10 with a newly formed carboxylic ester group and an oxime group.

Quinine Warnings: Nitric Oxide may enhance the adverse/toxic effect of Methemoglobinemia.

https://en.m.wikipedia.org/wiki/Methemoglobinemia

https://en.m.wikipedia.org/wiki/Methylene_blue

Nitrates are suspected to cause methemoglobinemia.

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https://en.m.wikipedia.org/wiki/Methemoglobinemia

https://en.m.wikipedia.org/wiki/Methylene_blue

https://en.m.wikipedia.org/wiki/Dapsone

https://en.m.wikipedia.org/wiki/TauRx_Therapeutics

https://en.m.wikipedia.org/wiki/Tau_protein

https://en.m.wikipedia.org/wiki/Alpha-synuclein

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Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension

https://pubmed.ncbi.nlm.nih.gov/11427637/

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Adrenochrome
Methemoglobin
Methemoglobinemia
Methylene Blue

Adrenochrome, an oxidation product of epinephrine which can convert hemoglobin into methemoglobin.

Nitrates are suspected to cause methemoglobinemia.

Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension.

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Methaemoglobin and COHb in patients with malaria

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118161/

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(MDMA)
Ecstasy Molly (E)
Methyl ​Enedioxy​
Methamphetamine

methylenedioxymethamphetamine, a stimulant drug that is chemically related to mescaline and amphetamine

overproduction of nitricoxide (NO) may participate in the dopaminergic damage induced by MDMA.

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https://en.m.wikipedia.org/wiki/MDMA

https://en.m.wikipedia.org/wiki/3-Methoxy-4-methylamphetamine

https://en.m.wikipedia.org/wiki/Adrenochrome

https://en.m.wikipedia.org/wiki/Carbazochrome

https://en.m.wikipedia.org/wiki/Vasoprotective

https://en.m.wikipedia.org/wiki/Estrogen

https://en.m.wikipedia.org/wiki/Estrone

https://en.m.wikipedia.org/wiki/Ergosterol

https://en.m.wikipedia.org/wiki/Ergocalciferol

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MDMA
Ecstasy
Methamphetamine
Adrenochrome
Carbazochrome
Vasoprotective
Estrogen
Estrone
Ergosterol
Ergocalciferol
D2

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Role of nitric oxide pathway in the conditioned rewarding effects of MDMA in mice

https://pubmed.ncbi.nlm.nih.gov/28479264/

Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice

https://pubmed.ncbi.nlm.nih.gov/24284821/

Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice

https://www.sciencedirect.com/science/article/abs/pii/S1089860319303532

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nitrate
nitrite

https://www.verywellmind.com/what-are-poppers-22094

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Adrenochrome
Methemoglobin
Methemoglobinemia
Methylene Blue

Adrenochrome, an oxidation product of epinephrine which can convert hemoglobin into methemoglobin.

Nitrates are suspected to cause methemoglobinemia.

Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension.

methylenedioxymethamphetamine, a stimulant drug that is chemically related to mescaline and amphetamine.

MDMA
Ecstasy
Methamphetamine
Adrenochrome
Carbazochrome
Vasoprotective
Estrogen
Estrone
Ergosterol
Ergocalciferol
D2

Role of nitric oxide pathway in the conditioned rewarding effects of MDMA in mice.

Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice.

overproduction of nitricoxide (NO) may participate in the dopaminergic damage induced by MDMA.

methylenedioxymethamphetamine, a stimulant drug that is chemically related to mescaline and amphetamine.