Expression of stem cell pluripotency markers in amniotic fluid cells

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Entry
A heterogeneous pool of cells
amniocytes, stem cells
transcription compatible with its characteristics
regulators and cell surface antigens
embryonic or
known as fetal stem cells.
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containing amniocytes
amniotic fluid from both the fetus and the fetus
stem cells shed from the amniotic membrane
Since it is a rich structure, root
cell acquisition and characterization
used in their work. amniotic
fluid is easily obtained in the first trimester of pregnancy.
obtaining amniotic fluid
culture of cells (AFC) and
easy and inexpensive to store,
Genetic diseases of AFCs, drug development
use in applications such as
caused. In recent years, AFCs
multipotent epidermal, mesenchymal,
hematopoietic and neuronal stem cells
obtain data on the character
has been done.
2 Differentiation into all cell types
embryonic root
use of cells (ESC) in regenerative medicine
There are ethical concerns about
induced pluripotent cells (iPSC)
difficulty in producing and reproducing
is happening. Therefore, the amniotic root
cells; disease modeling, cellular
regeneration, wound healing, congenital genetics
treatment of diseases and tissue engineering
use for such purposes is important.
3
Heterogeneity in the amniotic cell pool
fully explain the stages of differentiation in the structure.
incomplete and primitive form
cells more easily than iPSCs
can be programmed.
4 Amniocytes
they are pluripotent; mesenchymal,
endodermal and ectodermal origin
can be transformed into cells and thus
AFCs in cardiomyocyte, hepatocytes, kidney
and many different cells, such as nerve cells
was found to differ by type.
5
Galende E. et al.4; of AFCs
in cell and tissue treatments, from the same individual
iPSCs created by
due to the activity
investigated its usability. This
terminally differentiated by working
amniotic skin cells regenerate
programmed, twice as fast as iPSCs
and more than 200 times more stem cells
has been obtained. This highly effective
morphology and growth of cells
characteristics, antigenic stem cell
markers, stem cell gene expression, telomerase
activity, in-vitro and in-vivo differentiation
It has been shown to be similar to ESCs in terms of
Thus, more amniotic stem cells
young, epigenetically embryonic
more cell-like, speed and efficiency
more convenient than conventional iPSCs
showing that; stem cells
a new source of cell types in their treatments
suggest the use of amniocyte as
they lasted. Again, in studies
AFCs are easier and more stable than iPSCs.
can be reprogrammed in such a way that
expression of stem cell markers by cells
continuously protected and transcriptomic
as more similar to ESCs
shown.
6 Ditadi A. et al.7
erythroid, myeloid, and lymphoid
able to differentiate into hematopoietic cells
has shown.