Yeah I'm not sure there are either currently. I think a lot of these "unknowns" might be coming from our relatively limited understanding. If cancer is a "genetics" problem, and we see no change in the genome as a whole (I mean that in a single cell kind of way), then it has to be something impacting expression or hidden epigenomic changes. That's my limited intuition at least. I've done some transcriptomic analysis and it is incredibly difficult to interpret because proteins are malleable and have a ton of functionality. What it may do in this organ, is incredibly different than that organ.

I see that you are a scientist. What are your favorite topics of study?