The Ledger Nano S manages Neo (NEO) tokens. It works on Windows (7+), Mac (10.8+), Linux or Chrome OS. It requires Google Chrome or Chromium, and one USB port to plug your Ledger Nano S. Note that it doesn't work on Android and iOS.
If you have a Nano S, it must be updated to 1.3.1 firmware at least.
The Nano and the HW.1 don't support Neo. The Blue will support it soon.
Please find the following link you will have comple description.
https://support.ledgerwallet.com/hc/en-us/articles/115005530425-How-to-install-and-use-Neo-NEO-