Trying a different nootropic, this time Adrafinil which is a variation of modafinil which is a well known popular nootrpic.
I got tired of Phenibut, Its not working for me anymore just makes my tired and depressed and almost asleep while driving so its dangerous. heres some info:
"Adrafinil is a drug that makes users feel awake and alert. It is a popular stimulant because it has few side effects and does not require a prescription in many countries
Adrafinil is a non-amphetamine psychostimulant. It reduces drowsiness but does not increase heart rate or anxiety [R].
As a prodrug (an inactive drug that breaks down to the active drug) for the prescription stimulant modafinil, adrafinil becomes active by converting to modafinil in the body.
Adrafinil has a short biological half-life (the time it takes a substance to lose half of its biological activity) of 1 hour. It converts to modafinil, which has a 12 to 15-hour half-life. This means that the user will feel effects many hours after consumption [R].
Adrafinil produces its effects using the same mechanisms as modafinil. They include:
Increasing dopamine [R, R, R, R, R, R, R, R].
Increasing serotonin [R, R, R, R, R].
Increasing norepinephrine [R, R, R].
Increasing histamine release via orexin [R, R, R, R, R].
Increasing glutamate and decreasing GABA [R, R, R, R, R, R].
Uses of Adrafinil
Because adrafinil becomes active by converting to modafinil, both drugs have similar effects. The following studies highlight the research conducted on adrafinil.
Adrafinil improved slow thought and movement (psychomotor impairment) compared to an antidepressant (clomipramine) in a study of 70 depressed older adults [R].
Adrafinil increased participants’ ability to perform daily activities in a study (RCT) of 548 older adults with attention and memory problems [R].
In a study (RCT) of 10 elderly adults, adrafinil decreased brain waves associated with sleep (slow wave delta and theta wavelengths and increased brain waves associated with engagement in the present (alpha wavelengths) [R, R].
In multiple studies (including 1 DB-RCT) of 471 adults, adrafinil lowered symptoms of depression [R].
Adrafinil reduced symptoms of depression similar to an antidepressant (clomipramine) in a study of 70 depressed patients. The group receiving clomipramine reported frequent side effects, but adrafinil was well-tolerated [R].
In studies of 951 older adults (including 1 DB-RCT and 1 RCT), adrafinil reduced forgetfulness, and improved information recalls [R].
Adrafinil Improves Reaction Speed
In a study (DB-RCT) of 48 elderly adults with attention and processing speed problems, adrafinil reduced reaction time on a psychological test [R].
Adrafinil May Improve Learning
In aged beagle dogs (a model of human aging and cognitive decline), adrafinil improved performance and speed of learning on a pattern recognition task [R, R].
However, the same dose of adrafinil also lowered working memory (the ability to recall and apply relevant information during an activity) in aged beagle dogs [R].
Advantages of Adrafinil Over Other Stimulants
Many stimulants produce frequent side effects including appetite loss, sleep problems, and mood disturbances. They can also be addictive [R, R].
Adrafinil Produces Few Side Effects
Appetite loss, sleep problems, and mood disturbances are rarely reported with adrafinil use in human and animal studies [R, R, R].
Adrafinil Has Low Addiction Potential
Modafinil, the active product of adrafinil, was taken for 3 years without causing tolerance or dependence in a study of 42 participants with excessive sleepiness and narcolepsy [R]."
