There is only 1 game that I put up with having anti-cheat crap in it and that's VRChat, using easy anti-cheat, which for the most part is been painless to use and doesn't run all the time afaik.

Vanguard on the other hand.. holy shit.. That thing is horrid, my brother went on about it once when he was trying to play some riot games.. It completely blocked his ability to use his drawing tablet.. because vanguard is stupid and also runs on ever boot. He's have to disable vanguard and reboot just to use his tablet its insane!

Kernal level anti-cheat needs banning in law honestly.. It's not even necessary.. look at valve they get on fine without it with dota 2 and CS2