Classical Proof of Work systems are becoming more and more threatened by 51% attacks. This is caused by the combination of at least two factors. One is that cryptocurrencies are now expensive enough to be attacked. The other factor is that PoW mining is becoming increasingly centralized, which is partly because of specialized hardware, like ASICs. In this centralized landscape, one could even rent some hashing power to attack a system. Here is a very informative site demonstrating this. It is likely that those systems that do not come up with an idea for protection against 51% attacks will be wiped out soon. Here we list some alternatives for the future, the information was gathered from the forums of Dash, Decred and ZenCash. Thanks for the community of these projects for their help!
Dash has a two-tier system, which consists of miners, as in PoW systems, and MasterNodes, who are special nodes staking 1000 Dash. MasterNodes are requared for InstantSend and PrivateSend. However, a normal transaction is not affected by MasterNodes, a normal transaction is handled by the PoW system. In the future, Dash will probably switch to so called collateralized mining.
A collateralized miner is a combined MasterNode and miner. In the future, Dash MasterNodes will require a complex set of specific hardware, including ASICs.
Step by step mining without proportionate ownership of MasterNodes will be prohibited, after that, mining will require so called "mining keys". This will lower energy consumption, as there is an upper limit how much one can mine. The collateralized mining will greatly reduce the chance of a 51% attack and contribute to the scalability of the network. It is supposed that this way the network could handle 50 MB blocks easily.
Another thing that might reduce the chance of a 51% attack is the BetterHashMiningProtocol update, where instead of pools, miners decide what will go into the next block, making the system more decentralized. This is not a planned update in Dash, but the idea was presented on the forum.
The system of Decred is a hybrid PoW/PoS. A 51% attack against Decred would be ~20 times more costly that of a classic PoW system, let's say Bitcoin. Here is an article describing this. Decred was based on memcoin2, but it also has elements from Proof of Activity.