One of the most important considerations is parking and traffic it will draw.

Neighbors (and sometimes code enforcement officers) will NOT be happy if you have tons of traffic coming and going (like a drug dealer, happy ending massages, etc or even legit things) OR if your business visitors don't have ample parking in your driveway/yard (and if it spills out on to the road). These situations can constitute code violations and make your "home office" not meet zoning restrictions (these vary from city/county to city/county).

The other consideration is whether you can have a separate and direct entrance for your customers/clients or do you have to walk them into and through your home.  If you don't have them coming to you (as if you do phone work from home or prepare and mail/email/fax what you do) then this is a non-issue.  Personally, I don't like them coming into my home and always had the separate entrance and area from the rest of the home; I like that much better.

Type work:  Almost anything you can do from a commercial office you can do from a home office if you set it up right (and subject to restrictions in your community ... city/county code and deed restrictions). With computers, email and fax and phones there is not much office work that can't be done from a home office.

Also a lot of phone work (customer satisfaction surverys/calling), medical transcription, paid typing, tax returns, legal work, tuitoring, music lessons, web design and computer work, bookkeeping, hairdressing, baby sitting, handicapped day care, etc.

Good luck.