Cannabis isn't indigenous to the United States. In fact tobacco really isn't a huge part of ceremonies and smoking. Actually kinnickinnic was smoked more and that was more of a blend of that and other herbs.

Smoking along with sharing food and hospitality is a huge cultural significant thing that all humans recognize.

And in fact tobacco is used more for burning in a smudge pot or a prayer bundle being thrown into a fire.

There are kinnickinnic and tobacco smoking blends.

However the medical uses of this plant?

Plus the fact that it can help heal alcohol addiction and other physical addictions as well as providing relief for so many ailments as well as relief from pain. Makes it a highly effective and important medicine for a medicine man.