Can't say much about botox, but the theory with not being able to frown leading to feeling less depressed makes a lot of sense to me.

A bit of MDMA on the other hand will make you smile from the bottom of your heart. So yeah! That's probably a lot more effective, too.

Since MDMA also has some short term and even possible long term effects on the serotonin system, though, it's probably involving some risk for the treatment to go sideways, too.

I think the key in treating depression is simply not to be found in any substance.

#GooglyEyes might help, though.