The level of depression that is not playing around from one of the strongest mutants has a huge impact.
In the House of M comic, knowing the fact that he wanted to be killed by other heroes due to what he did (destroying one city and killing several heroes, including Vision), he finally changed the reality of the world!
That is to say here, he changed the various things that should have happened, into something else. An example is, he made several mutants in the world disappear from the memories of others, and also he made mutants become again hostile to ordinary humans.
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