Feelings of sadness and loss can activate several parts of the human brain. When you feel sad and heartbroken, the activity in our part of the brain is called anterior. Feelings of being eliminated from the social environment, low self-confidence, and rejection will also trigger activity, especially in the back.

On the middle wall of the brain and is a very unique part. This is because ACC has emotional function (ability to manage feelings) as well as cognitive function (ability to think).

In the human body, there are many receptors aka recipient stimuli. These receptors function to channel signals that arise due to stimuli or changes that occur in the body. One type of receptor that is apparently abundant in ACC is the opioid receptor. This receptor will play a role when you feel happy or sad. When pleased, there will be an increase in work at the opioid receptor. Whereas when you are sad there will be a decrease in opioid endogenous receptors. This decrease in opioid receptors will also cause a decrease in the reward system within yourself, which makes you feel uncomfortable.

The pain that is received by the opioid receptor will be processed and converted into the activity of the nervous system so that it will bring physical discomfort and pain to the body, not to feelings. Why you can experience abdominal pain or chest tightness when broken heart.