As for most profitable currently its a toss up for me either ZBC miner though this gets expensive to play leader board prizes make it one I profit the most from.
https://www.zombiecoin.io/
However for those just starting fresh Beast Gardens is extremely popular as my NFT sales records would indicate.

You can easily profit from beast gardens with minimum monetary input where as Zombie Coin Miner would require a longer term larger investment to profit. Using the games auction market on Beast gardens I do a fairly sizable turn over buying & selling their NFTs & packs for a profit.

I sent a Spring NFT from Beast Gardens to the address provided.

The reason I single out Beast Gardens & Zombie Coin Miner is because currently my profits on either game is in excess of a few hundred dollars. However to profit I needed to put a decent amount into both collections without immediate return. Beast Gardens is much less risky right now so its the better option.

My all-time highest earning colection is Splinterlands which is on HIVE & WAX my profits on Splinterlands far exceed $10,000 over the last year but you have to have a $10 Spell book to keep the rewards from playing.
https://splinterlands.com?ref=chubb149

Splinterlands has the added benefit of not using WAX CPU or RAM making it cheaper to play in the long run. Hope this info helps a little & thanks for participating