Only two teams in Champions League history have overturned a deficit of three goals or more from the first leg in the knockout stages.
Deportivo La Coruna trailed AC Milan 4-1 in quarter-final in 2004 before advancing 5-4 on aggregate after winning 4-0 in Spain.
More recently, Barcelona overturned a 4-0 last-16 deficit against Paris St-Germain by winning 6-1 in the second leg at the Nou Camp last season.
Roma vs Barcelona ( Agg 1-4)
Manchester City vs Liverpool ( Agg 0-3)