Yes, we use the very ASUS board you showed (and a couple other similar ones by MSI and Cablecc) that allow you to use one PCI 16x slot in "bifurcated mode" to connect 4 2TB gen4 nvme drives, which we typically configure into a 4x raid0 8TB drive.

We've been using Ryzen 3960X and more recently 5950X systems that support PCI4 drives. We buy pre-tested bare-bones 5950X systems from a systems integrator, then populate them with better drives and a full complement of memory once we get them (integrators tend to overcharge for these latter items).