Just a thought on your thoughts: if nothing really matters isn't it that like saying that everything matters (the same, and therefore also, a LOT)?

...or perhaps that an alternative to the Universe doesn't care is that it does intimately care about absolutely everything, deeply and to the level of a blade of grass or the deepest shame/pain experienced by any Being?

Perception, creativity, opinion, concepts etc may be ways of slicing and dicing a unified whole into the illusion of separate parts.

It's a dance :)