Yes , life and everything challenges you more when you’re physically tired , I can relate with this because at some point I had an ailment called myasthenia gravis , which had to do with reflect muscles , so my limbs(hands and legs) were affected , walking was affected and my work being an artist was affected too, I made sure I stood steadfast in faith and didn’t get my mind affected and God saw me through the season. Your mind is the most powerful tool you have and you should guard it with all diligence. Challenges will surely come but how steadfast you can be is what counts.