Cushing syndrome occurs when the adrenal cortex becomes more active than necessary. Cushing's syndrome is caused by the effect of excessive corticosteroid medication, secondly by hyperplasia. Excessive production of corticosteroids can lead to many complications. The pitutary t gland secretes ACTH hormone but it releases too much ACTH for hormonal secretions and that too more than required, then this type of condition occurs. Pitutary tumor is also responsible for Cushing syndrome.
Clinical manifestation
Opthalmic
Cataracts
Glucoma
Cardiovascular
Hypertension
Heartfailure
Skeletal
Osteoporosis
Spontaneous fracture
Aseptic necrosis of femur
Vertebral compression fracture
Gestrointesinal
Peptic Ulcer
Pancreatitis
Muscular
Myopathy
Muscle weakness
Dermatologic
Thinning of skin
petechiae
ecchymoses
striae
acne
Phychiatric
Mood alterations
Psychoses
Immune function
Decreased inflammatory responses
Impaired would healing
Increased susceptibility to infection
Endocrine/ Metabolic
Truncal obesity
moon face
buffalo hump
Sodium retention
hypokalemia
metabolic alkalosis
Hyperglycemia
menstrual irregularities
impotence
negative nitrogen balance
altered calcium metbolism
adrenal suppression
Medical menagement
If it is cause by pitutary tumors instead of tumors of the adrenal cortex so treatment is directed at the pitutary glands. Remove glands by surgery which is known as Transsphenoidal hypophysectomy.
If this is a result of administration of corticosteroids, so please tepper dose of medication.
If bilateral adrenalectomy done so we need to replace hormone with oral medication for lifetime.
