One example of 'regression' is perhaps over-specialization. Knowledge is so vast, that the only way to be an expert today is to specialize in some very small area of knowledge. But then you lose 'wisdom', you lose the grand scheme of things, the top-of-the-mountain view. It's like being a new kind of ignorant. And unless we figure out a way to significantly extend our lifespans or brain capacities, it's only gonna get worse.