I finally printed your article out, took it aside and read it in a quiet place. This material is challenging for me, but still there was much to mine. I'm very interested in the immune response, which is really the heart of your article, especially immune responses that are generated far from the site of an event. Your speculation about psoriasis flares coincided exactly with where my mind was going as I finished your piece.
Systemic lupus came to mind. This disease is famously triggered by just about anything. An assault on the body sends signals throughout to go on high alert, and a flare, unrelated to the original event, will ensue. This is similar to a psoriasis flare. Of course, in lupus, while the original antagonist might not be dangerous, the ensuing flare can be.
Very perplexing for lupus patients and treating physicians. Whenever an assault on the body (or mind) occurs, there is always consideration of an indirectly related immune response.
While this paper was hard for me to work my way through, because the technical language is unfamiliar to me, still there was much value in reading.
Thank you for taking the time to write and explain these important matters. You turn SteemSTEM into a laboratory for learning--for scientists and non-scientists.