There's a lot of funny projects out there in the DeFi space, but it's difficult to actually make some decent profit on them unless you're somewhat focussed, and exit the respective peojects before it's too late. Of course, these 1000+% APYs cannot be sustainable, so if you're too late to the party you might end up being the one making it profitable...for someone else.

If you feel like playing around also with smaller amounts I can recommend DeFi on the EOS network. With no gas fees it's much easier to get into small positions, but total value locked is also healthy (even if not comparable with ETH) if you want to go bigger ;-)