Wow, you're very knowledgeable. Thank you for your insight.

As for your question, from what I've read, aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2.

COX-1 is involved in pain, promoting clotting, and protecting the stomach
COX-2 is involved in the pain produced by inflammation

COX-2 inhibitors (not aspirin) are effective against inflammation and avoid damage to the GI tract, but they increase the risk of blood clots.

AnGes, Inc. is doing a 12 month study injecting a NF-kB Decoy directly into the intervertebral discs of patients with chronic discogenic low back pain (DLBP). Hopefully without the problems of COX inhibitors, but it will most likely come with new side effects.

More info on all this here:

1. http://www.biology-pages.info/I/Inflammation.html
2. https://en.wikipedia.org/wiki/Aspirin
3. http://pipelinereview.com/index.php/2018022867489/DNA-RNA-and-Cells/AnGes-Announces-First-Patient-Treated-with-NF-kappa-B-Decoy-in-Phase-Ib-Study-to-Treat-Discogenic-Low-Back-Pain.html

If your target is inflammation in the arteries, Nitric Oxide derived from L-arginine supplementation can be very effective. Some are much better than others. I personally like the chocolate chewables CardioForLife at https://www.healthguardian.com/product/name/cardioforlife/id/1930190

More info about nitric oxide here:

1. http://www.biology-pages.info/N/NO.html
2. https://en.wikipedia.org/wiki/Nitric_oxide#Biological_functions

OOOOPS... My answer got a bit too long and off topic. I need to go now. Thanks again for your comment.