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"Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are two neurotrophins—signaling compounds that act as neuronal growth factors. They influence processes that promote the development, maintenance, survival and function of the nervous system. Because of their key roles in these processes, they are preferential targets for nutritional support.
BDNF is of particular relevance in the context of neurogenesis. BDNF has been associated with the proliferation of neuronal precursors and the differentiation, maturation and integration of newborn neurons in the hippocampus. BDNF has also been positively linked to dendritic branching, length, and complexity, and to synaptogenesis and synaptic maturation.25–28 NGF has been associated with the proliferation, growth, maintenance and survival of neurons, particularly peripheral nerve growth and myelin production.29
There are several ingredients in QUALIA MIND that may support the production of neurotrophins.* The production and action of BDNF may be supported by Ginkgo biloba,30 Taurine,31 L-Theanine,32 and the combination of Vitamin B12 and DHA.33 The synthesis and activity of NGF may be supported by Huperzine A,34 PQQ,35 and Phosphatidylserine.36 As a consequence of this support of neurotrophin production, these ingredients may contribute to supporting specifics steps in the process of neuronal differentiation and growth.*
In addition to their support of neurotrophic factors, Ginkgo biloba may support progenitor cell proliferation and differentiation and neuronal survival.30,37 Huperzine A may support proliferation of hippocampal neural stem cells.34 Vitamin D may support the synthesis of neurotrophic factors and neurotrophin receptors, and thereby support NSC proliferation and differentiation, neuronal maturation and growth, neuronal survival, and synaptogenesis.*38–40
There are other ingredients that may also participate in pro-neurogenic, pro-neuritogenic or pro-synaptogenic processes, even though it is still unclear if they are able to support neurotrophin production. For example, Rhodiola rosea has been reported to support neurogenesis and neuronal regeneration.41,42 Uridine Monophosphate supports neurite outgrowth and the proliferation of dendritic spines.43,44 Bacopa monnieri also appears to support neurite branching and proliferation.*45
Several B vitamins appear to be involved in neurogenesis and might be particularly important under circumstances characterized by higher stress or injury. Vitamin B1 (Thiamin or Benfotiamine) might help prevent stress-induced inhibition of hippocampal neurogenesis.46 Vitamin B3 (Niacinamide)—a substrate to produce NAD+—might play a significant role in regenerative neurogenesis after injury or trauma.47 Vitamin B6 (Pyridoxine 5-Phosphate) appears to be involved in promoting neurogenesis in in the dentate gyrus.*48
Choline precursors capable of crossing the blood-brain barrier support neurogenesis in animal experiments. Citicoline supports neurogenesis in the dentate gyrus and subventricular zone, and may also be important for regenerative neurogenesis after injury or trauma.49 Alpha Glycerylphosphorylcholine appears to promote neurogenesis and have neuroprotective effects.50
Acetyl-L-Carnitine might enhance NSC proliferation and adult hippocampal neurogenesis by regulating proneural genes and cell survival related signals.*51
Why support neurogenesis?
Neurogenesis is an important mechanism of cognitive adaptation. Supplements and nootropics may allow us to support the molecular and cellular mechanisms that contribute to the maintenance of the biochemical processes that drive neurogenesis.* Importantly, supplements and nootropics may contribute to the brain’s intrinsic ability to upregulate neurogenesis in response to cognitively demanding contexts and or circumstances that produce a greater need for regenerative support.*"