Cholestasis in Pregnancy:
• It 2nd most common cause of jaundice in pregnancy(m/c being hepatitis in pregnancy) • It is characterized by accumulation of bile acids in liver.
Clinical Features: •
Manifestation appears beyond 30 weeks (i:e in 3rd trimester) and occasionally in late 2nd trimester. •1st symptom to appear is pruritis-which has a predilection for the palms and soles. (pruritis appears 3 weeks before lab findings) • Jaundice is sligh-t bilirubin levels rarely exceed 5mg. • Recurs in subsequent pregnancies and so OCP’s are contraindicated in females with H/O cholestasis during pregnancy. • M/c in twin pregnancy.