I do not think anyone has had a real-time experiment with the digestive system of a human like army surgeon William Beaumont. While this is a case of science, it is also a case where ethics and moral standards weren't followed. Anyway, I will be sharing a glimpse into the story of how digestion was researched by a person known as the "Father of Gastric Physiology".
The journey to understanding how the stomach functions began on a fateful day, June 6, 1822, when Alexis St. Martin, a 19-year-old French Canadian, found himself at the wrong end of a musket's discharge. The shot struck his upper abdomen, causing severe injuries that would have likely proven fatal in the absence of modern medical interventions. But this was a different era, with medical science in its infancy.
In our world of advanced technology and innovations, the possibility of him surviving is very low, so his surviving the event was a wonder at that point in time. When he didn't die, army surgeon William Beaumont was summoned. Beaumont found that the asides from his abdominal wall were torn, a hole was created in his stomach and everything he had consumed was dripping out.
At this point in time, medical science was in his infancy, so there was really nothing much that could be done for him, but Alexis St. Martin was saved as Beaumont was able to devise a means of passing nutrition into his body rectally since food and drinks given to him were leaking out of his body. Alexis St. Martin also got infection as expected but soon recovered but the hole in his stomach and abdomen didn't close, so Beaumont decided to bandage the wound allowing food to stay in the stomach.
Even during operational procedures, physicians try to prevent a fistula that can be damaging, so you can imagine that a fistula was inevitable in Alexis St. Martin's case. His stomach began to adhere to the skin of his abdomen forming a gastrocuteneous fistula, and this got the attention of the doctor as his abdomen had a hole but the stomach was attaching to it.
Unintentionally, St. Martin's condition had created a unique opportunity for Beaumont to explore the mysteries of the gastrointestinal tract firsthand. Prior to these experiments, scientific theories about digestion were diverse and often conflicting. Some believed that food underwent fermentation in the stomach due to its heat, while others posited that it decayed. The nature of digestion was hotly debated, with scientists divided on whether it was primarily a mechanical or chemical process.
Just as I guessed, Beaumont began to use Alexis St. Martin as a live experiment. With St. Martin as his willing (yet ethically questionable) subject, Beaumont embarked on a series of over 250 experiments. These experiments delved into the intricacies of digestion by lowering various foods directly into St. Martin's stomach using a string. Beaumont meticulously observed how long different foods took to digest and how they were processed in real-time. He collected stomach acid samples for analysis, shedding light on the dual mechanical and chemical aspects of digestion.
Among his groundbreaking findings, Beaumont demonstrated that stomach acid was present only during the digestion of food. He also highlighted the role of stomach acid in preventing infections, a crucial protective function. His experiments reshaped our understanding of digestion, challenging earlier misconceptions.
William Beaumont and Alexis St. Martin provide a captivating glimpse into the intersection of science, medicine, and ethics. It underscores the importance of ethical considerations in scientific research although a remarkable emerged from the unconventional circumstances. There is no doubt that Beaumont's pioneering work paved the way for a deeper understanding of our digestive system, and left a lasting legacy in the world of medical history.